The risk of pregnancy loss has long been known to increase with advancing age. The data obtained from oocyte donation has shown that a recipient's risk of SAB is directly related to the age of the oocyte donor rather than to the recipient's age. This implies that the risk of SAB is a function of oocyte properties rather than uterine receptivity.
In a study of couples with RPL, a negative evaluation for RPL, and poor response to gonadotropins, oocyte donation resulted in a delivery rate of 85.7% and an SAB rate of 11.1%. Again, this indicates that oocyte quality is a determinant of pregnancy outcome and may play a causative role in RPL.
Suggested Reading
