F O R   P H Y S I C I A N S – resources
Recurrent Pregnancy Loss 
Introduction
Genetic Causes
Uterine Abnormalities
Endocrine Causes
Autoimmunity
Other Coagulation Abnormalities
Alloimmune Causes
Oocyte Abnormalities
Evaluation of Recurrent Pregnancy Loss
Treatment

Introduction
Approximately 15 to 20% of clinically recognized pregnancies result in a spontaneous abortion (SAB). If all pregnancies are taken into consideration, including those that are too early to be clinically recognized, it is estimated that 30% fail. Recurrent pregnancy loss (RPL) is defined as the occurrence of two consecutive spontaneous abortions or, more strictly, three or more consecutive losses. About 1 to 2% of couples have 3 or more consecutive losses and as many as 5% of couples have at least 2 losses. Primary RPL refers to couples that have never had a live birth, while secondary RPL refers to those who have had repetitive losses following a successful pregnancy.

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