At CRE, we understand the importance of teamwork. That is why our patients' care is closely coordinated with their referring physicians. This section of our web site is provided as a resource to all physicians. It contains specific information and cutting edge articles to help keep you up to date on what's new in the field of reproductive endocrinology.
Mitochondria in human oogenesis and preimplantation embryogenesis: engines of metabolism, ionic regulation and developmental competence
Mitochondria are the most abundant organelles in the mammalian oocyte and early embryo. While their role in ATP production has long been known, only recently has their contribution to oocyte and embryo competence been investigated in the human.
High-polarized mitochondria are spatially polarized in human oocytes and early embryos in stable subplasmalemmal domains: developmental significance and the concept of vanguard mitochondria
The spatial specificity and stability of subplasmalemmal domains of high-polarized mitochondria in human oocytes and cleavage stage embryos were investigated in instances where changes in pericortical/subplasmalemmal organization resulted in the corresponding cytoplasm becoming translucent and largely devoid of mitochondria, either by experimental manipulation or as a result of spontaneous, stage-specific morphodynamic processes.
Occurrence of maternal and paternal spindles in unfertilized human oocytes: possible relationship to nucleation defects after silent fertilization
After you've read the article, Click here to read a bio on Dr. Johnathan Van Blerkom. Both of these are Adobe Acrobat files. Click on the link below to get the free Adobe Reader if you don't already have it.
A microscopic and biochemical study of fragmentation phenotypes in stage-appropriate human embryos
The occurrence of a pleiomorphic population of cytoplasmic fragments is a common characteristic of early human embryos fertilized in vitro.
Differential effects of repeated ovarian stimulation on cytoplasmic and spindle organization in metaphase II mouse oocytes matured in vivo and in vitro.
The effects of four rounds of ovarian stimulation spaced 1-6 weeks apart on the normality of methaphase II (MII) spindle formation, chromosomal allignment and cytoplasmic organization were examined in intact ovulated mouse oocytes and at MII for oocytes obtained at the germinal vesicle stage from the same ovaries and matured in vitro.
Transition from OI/IVF to Donor Oocytes
Since the first successful in vitro fertilization cycle was reported in 1978, efforts have been directed toward increasing the chance of success with the procedure.
Premature Ovarian Failure
Premature ovarian failure (POF) is defined by most authors as the loss of ovarian function before the age of 40.
Recurrent Pregnancy Loss
Approximately 15 to 20% of clinically recognized pregnancies result in a spontaneous abortion (SAB).
Mitochondrial DNA Defects
Differential mitochondrial distribution in human pronuclear embryos leads to disproportionate inheritance between blastomeres...
Assisted Reproductive Technology (ART)
Approximately one in ten couples of reproductive age are affected by infertility. This translates into approximately 6 million couples in the United States...
Selective Estrogen Receptor Modulators (SERM)
The menopausal state is characterized by a decrease in ovarian production of estrogens resulting in an increase in the risk of osteoporosis, cardiovascular disease and Alzheimer's disease...
